www.leukaemiacare.org.uk16
CML
Patients with a chronic leukaemia,
such as chronic myeloid
leukaemia, may be treated with
a tyrosine kinase inhibitor, also
known as a TKI.
While many people may refer to
a TKI as a form of chemotherapy,
a TKI is a targeted therapy which
will be taken for many years.
You may find mixed information
online as to whether you should
use a condom if you or your
partner is being treated with a TKI
and this information can be very
confusing.
Many of the key CML experts both
in the UK and worldwide say that
a condom isn’t necessary as the
levels of treatment in secretions
such as semen or vaginal fluids
would be very low and would not
interfere with a partner.
Although this booklet is not
necessarily about fertility, it is
important to raise the issue of
contraception with female CML
patients of a child bearing age.
Studies show no suggestion
of any problems in pregnancy,
delivery or any increase in
congenital abnormalities when
the father is being treated for
CML. For male patients, fathering
children could be achieved
without interruption of treatment.
For a female patient being
treated with TKIs, this is not the
case. TKI’s are teratogenic drugs
which means they can disturb
the development of the embryo
or foetus. Therefore, pregnancy
in women with CML is closely
monitored by a consultant.
Women with CML who aren’t
actively trying for a baby should
use a form of contraception to
prevent pregnancy. Having CML
does not mean you shouldn’t get
pregnant, however, it should be
discussed with your consultant.
There are a number of resources
online that discuss pregnancy
and CML. Leukaemia Care have a
video on their YouTube channel
from a world-renowned expert
on the subject, Professor Jane
Apperley. The charity has been
allowed to share the footage by
the CML advocates network and
can be found on their YouTube
channel at http://www.youtube.
com/c/leukaemiacare
Sex and chronic leukaemias